1. He always seems to fail at everything he tries, he's just a born loser.
Translation: Siempre parece fallar en todo lo que intenta, es simplemente un perdedor nato.

2. No matter how hard he works, he can never seem to catch a break. He's just a born loser.
Translation: No importa cuánto trabaje, nunca parece tener suerte. Es simplemente un perdedor nato.

3. She's been unlucky in love so many times, she's starting to feel like a born loser.
Translation: Ha tenido mala suerte en el amor tantas veces, que está empezando a sentirse como una perdedora nata.

4. He always seems to be in the wrong place at the wrong time. He's just a born loser.
Translation: Siempre parece estar en el lugar equivocado en el momento equivocado. Es simplemente un perdedor nato.

5. No matter how much he practices, he can never seem to win a game. He's just a born loser.
Translation: No importa cuánto practique, nunca parece ganar un juego. Es simplemente un perdedor nato.

6. She's always the one who ends up getting hurt in relationships. She's starting to think she's a born loser.
Translation: Siempre es la que termina lastimada en las relaciones. Está empezando a pensar que es una perdedora nata.